منابع مشابه
Identification of the Common Origins of Osteoclasts, Macrophages, and Dendritic Cells in Human Hematopoiesis
Osteoclasts (OCs) originate from the myeloid cell lineage, but the successive steps in their lineage commitment are ill-defined, especially in humans. To clarify OC origin, we sorted cell populations from pediatric bone marrow (BM) by flow cytometry and assessed their differentiation potential in vitro. Within the CD11b(-)CD34(+)c-KIT(+) BM cell population, OC-differentiation potential was rest...
متن کاملHematopoiesis.
Enormous numbers of adult blood cells are constantly regenerated throughout life from hematopoietic stem cells through a series of progenitor stages. Accessibility, robust functional assays, well-established prospective isolation, and successful clinical application made hematopoiesis the classical mammalian stem cell system. Most of the basic concepts of stem cell biology have been defined in ...
متن کاملHematopoiesis and Stem Cells
The low incidence of CFU-F significantly complicates the isolation of homogeneous populations of mouse bone marrow stromal cells (BMSCs), a common problem being contamination with hematopoietic cells. Taking advantage of burgeoning evidence demonstrating the perivascular location of stromal cell stem/ progenitors, we hypothesized that a potential reason for the low yield of mouse BMSCs is the f...
متن کاملHematopoiesis and Stem Cells
Nicholas A. Watkins,1 Arief Gusnanto,2 Bernard de Bono,3 Subhajyoti De,4 Diego Miranda-Saavedra,5 Debbie L. Hardie,6 Will G. J. Angenent,7 Antony P. Attwood,7 Peter D. Ellis,7 Wendy Erber,8 Nicola S. Foad,1 Stephen F. Garner,1 Clare M. Isacke,9 Jennifer Jolley,1 Kerstin Koch,1 Iain C. Macaulay,1 Sarah L. Morley,1 Augusto Rendon,1 Kate M. Rice,7 Niall Taylor,1 Daphne C. Thijssen-Timmer,10 Marloe...
متن کاملHematopoiesis and Stem Cells
The c-myb transcription factor is highly expressed in immature hematopoietic cells and down-regulated during differentiation. To define its role during the hematopoietic lineage commitment, we silenced c-myb in human CD34 hematopoietic stem/ progenitor cells. Noteworthy, c-myb silencing increased the commitment capacity toward the macrophage and megakaryocyte lineages, whereas erythroid differe...
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ژورنال
عنوان ژورنال: BoneKEy Reports
سال: 2012
ISSN: 2047-6396
DOI: 10.1038/bonekey.2012.46